VEGF Receptor 2 Polyclonal antibody

VEGF Receptor 2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

IHC, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 18975-1-AP

Synonyms

CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGF Receptor 2, VEGFR, VEGFR 2, VEGFR2

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Validation Data Gallery

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  IHC staining of human breast cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human breast cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

• 

  IHC staining of human placenta using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 18975-1-AP (VEGF Receptor 2 antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human placenta using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 18975-1-AP (VEGF Receptor 2 antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human colon cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Published Applications

• IHC: See 1 publications below

Product Information

18975-1-AP targets VEGF Receptor 2 in IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
• Calculated Molecular Weight: 152 kDa
• GenBank Accession Number: NM_002253
• Gene Symbol: KDR
• Gene ID (NCBI): 3791
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

Publications

Species	Application	Title
mouse	IHC	Kidney Int; TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.; Authors - Xu Chang C