KCNE2 Polyclonal antibody

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  WB analysis using 17920-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 17920-1-AP (KCNE2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

KCNE2 Polyclonal Antibody for WB, ELISA

Cat No. 17920-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

mouse, rat

Applications

WB, ELISA

Synonyms

MinK-related peptide 1, MinK related peptide 1, Minimum potassium ion channel-related peptide 1, LQT6, LQT5

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Tested Applications

• Positive WB detected in: mouse kidney tissue, mouse pancreas tissue, rat kidney tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

17920-1-AP targets KCNE2 in WB, ELISA applications and shows reactivity with mouse, rat samples.

• Tested Reactivity: mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: KCNE2 fusion protein Ag12336
• Full Name: potassium voltage-gated channel, Isk-related family, member 2
• Calculated Molecular Weight: 123 aa, 14 kDa
• Observed Molecular Weight: 30 kDa
• GenBank Accession Number: BC093892
• Gene Symbol: KCNE2
• Gene ID (NCBI): 9992
• RRID: AB_3669283
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9Y6J6
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2, also known as LQT5, LQT6, ATFB4, and MIRP1) functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PMID: 10219239; 11034315; 11101505; 12185453; 20533308). KCNE2 beta subunit modulates the gating kinetics and enhances the stability of the channel complex (PMID: 10219239; 11034315; 11101505; 12185453; 20533308). It is expressed in various parts of the heart, with higher levels observed in the ventricles and Purkinje tissues compared to the atria (PMID: 39272981). KCNE2 has three forms, such as the core (15 kDa), singly glycosylated (20 kDa), and doubly glycosylated (25 kDa) forms (PMID: 15066947).