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Integrin beta 3 Recombinant antibody, PBS Only

Integrin beta 3 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

230292A10

Cat no : 83053-6-PBS

Synonyms

CD61, GP3A, GPIIIa, Integrin beta 3, ITGB3

Validation Data Gallery

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  • Western Blot (WB) analysis of human peripheral blood platelets using Integrin beta 3 Recombinant antibody (83053-6-RR)

    WB analysis of human peripheral blood platelets using 83053-6-RR (same clone as 83053-6-PBS)

    human peripheral blood platelets were subjected to SDS PAGE followed by western blot with 83053-6-RR (Integrin beta-3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83053-6-PBS in a different storage buffer formulation.

Product Information

83053-6-PBS targets Integrin beta 3 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide
Full Name integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Calculated Molecular Weight 87 kDa
Observed Molecular Weight100-110 kDa
GenBank Accession NumberBC127667
Gene Symbol Integrin beta 3
Gene ID (NCBI) 3690
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Integrin beta-3, also named as CD61 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin beta-3 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Human integrin beta-3 has a calculated molecular weight of 87 kDa. As a result of glycosylation, the apparent molecular mass of integrin beta-3 is approximately 90-110 kDa.