Integrin Beta 4 Monoclonal antibody, PBS Only
Integrin Beta 4 Monoclonal Antibody for WB, IF/ICC, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
WB, IF/ICC, ELISA
Conjugate
Unconjugated
CloneNo.
1C2A11
Cat no : 66922-2-PBS
Synonyms
Validation Data Gallery
Product Information
66922-2-PBS targets Integrin Beta 4 in WB, IF/ICC, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | Integrin Beta 4 fusion protein Ag17395 |
Full Name | integrin, beta 4 |
Calculated Molecular Weight | 1752 aa, 195 kDa |
Observed Molecular Weight | 200-210 kDa |
GenBank Accession Number | BC126411 |
Gene Symbol | Integrin beta 4 |
Gene ID (NCBI) | 3691 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-4 is predominantly expressed in squamous epithelial cells, endothelial cells, immature thymocytes, Schwann cells, and fibroblasts of the peripheral nervous system (PMID: 28084395). Integrin beta-4 pairs with alpha-6, and the heterodimeric integrin alpha-6/beta-4 is a receptor for laminin. Integrin alpha-6/beta-4 plays a critical structural role in the hemidesmosome of epithelial cells, and also plays a role in the invasive and metastatic phenotype of various cancers.