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ITM2C Polyclonal antibody, PBS Only

ITM2C Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 13601-1-PBS

Synonyms

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human colon tissue using ITM2C Polyclonal antibody (13601-1-AP)

    IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon tissue using ITM2C Polyclonal antibody (13601-1-AP)

    IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

Product Information

13601-1-PBS targets ITM2C in IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ITM2C fusion protein Ag3876
Full Name integral membrane protein 2C
Calculated Molecular Weight230aa,26 kDa; 267aa,30 kDa
Observed Molecular Weight 30 kDa
GenBank Accession NumberBC025742
Gene Symbol ITM2C
Gene ID (NCBI) 81618
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.