- Featured Product
- KD/KO Validated
Inhibin Beta A Polyclonal antibody
Inhibin Beta A Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (2)
Applications
WB, IHC, IF, ELISA
Conjugate
Unconjugated
Cat no : 10651-1-AP
Synonyms
Validation Data Gallery
Published Applications
| KD/KO | See 1 publications below |
| WB | See 4 publications below |
| IHC | See 11 publications below |
| IF | See 3 publications below |
Product Information
10651-1-AP targets Inhibin Beta A in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Inhibin Beta A fusion protein Ag1001 |
| Full Name | inhibin, beta A |
| Calculated Molecular Weight | 47 kDa |
| Observed Molecular Weight | 42 kDa |
| GenBank Accession Number | BC007858 |
| Gene Symbol | Inhibin beta A |
| Gene ID (NCBI) | 3624 |
| RRID | AB_2125851 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Inhibin is a 32-kD dimeric glycoprotein consisting of an alpha subunit and one of two beta subunits (beta A or beta B) leading to inhibin A or B, respectively, which was isolated and cloned on the basis of its ability to inhibit FSH release from the pituitary. Inhibin beta A forms a disulfide-linked homo-dimer known as activin A, which has been implicated in multiple biologic processes, including neoplastic progression. The inhibin beta A can also bind the beta B and A isoforms to form activin AB and inhibin, respectively.
Publications
| Species | Application | Title |
|---|---|---|
Nat Commun Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation. | ||
Development Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination. | ||
PLoS One Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice. | ||
Transl Oncol Multiregion single cell analysis reveals a novel subtype of cancer-associated fibroblasts located in the hypoxic tumor microenvironment in colorectal cancer | ||
BMC Cancer Esophageal squamous cell carcinoma invasion is inhibited by Activin A in ACVRIB-positive cells. |
