IL-23R Recombinant monoclonal antibody

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  WB analysis using 83918-3-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 83918-3-RR (IL23R antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

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  Affinity and Kinetic Characterization of 83918-3-RR

  Biolayer interferometry (BLl) kinetic assays of 83918-3-RR against Mouse IL-23R were performed. The affinity constant is 3.44 nM.

IL-23R Uni-rAb^® Recombinant Antibody for WB, ELISA

Cat No. 83918-3-RR

Clone No.240989A12

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Synonyms

Il23r, interleukin 23 receptor, IL 23R, IL 23 receptor, 240989A12

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Tested Applications

• Positive WB detected in: K-562 cells, Jurkat cells, RAW 264.7 cells

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

83918-3-RR targets IL-23R in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant protein

• Full Name: interleukin 23 receptor
• Calculated Molecular Weight: 73 kDa
• Observed Molecular Weight: 73 kDa
• Gene Symbol: Il23r
• Gene ID (NCBI): 209590
• RRID: AB_3671497
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q8K4B4
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Interleukin-23 receptor (IL-23R) is a type I cytokine receptor that plays a critical role in immune responses and inflammation. It forms a receptor complex with IL-12Rβ1 and is activated by the cytokine IL-23, which is primarily produced by dendritic cells and activated macrophages (PMID: 39796684). The genetic and epigenetic interactions in the IL-23R/IL-17 axis are associated with elevated expression of IL-17 and inflammatory bowel disease (IBD) pathogenesis (PMID: 21672939).