Anti-Human IL-5 Rabbit Recombinant Antibody, PBS Only

IL-5 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98178-1-PBS
Clone No.240915D12

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC (Intra)

IL5, Interleukin-5, Interleukin 5, IL 5, B-cell differentiation factor I

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

98178-1-PBS targets IL-5 in FC (Intra) applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein Predict reactive species
Full Name interleukin 5 (colony-stimulating factor, eosinophil)
Calculated Molecular Weight 134 aa, 15 kDa
GenBank Accession NumberBC066282
Gene Symbol IL5
Gene ID (NCBI) 3567
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP05113
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity. (PMID: 21986312, 22174445, 19819937, 16895557)

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