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IL-36 Gamma Polyclonal antibody

IL-36 Gamma Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 24723-1-AP

Synonyms

IL 1 epsilon, IL 1 related protein 2, IL 1F9, IL 1H1, IL 1RP2, IL1E, IL1F9, IL-1F9, IL1H1, IL1RP2, IL-36 gamma, IL-36γ, Interleukin 1 epsilon, Interleukin 1 family member 9, interleukin 1 family, member 9, Interleukin 1 homolog 1



Tested Applications

Positive IHC detected inhuman colon cancer tissue, human pancreas tissue, human ovary tumor tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

24723-1-AP targets IL-36 Gamma in WB, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IL-36 Gamma fusion protein Ag21489
Full Name interleukin 1 family, member 9
Calculated Molecular Weight 169 aa, 19 kDa
GenBank Accession NumberBC098337
Gene Symbol IL-36 gamma/IL-1F9
Gene ID (NCBI) 56300
RRIDAB_2879690
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

IL-36 Gamma is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection.

Protocols

Product Specific Protocols
IHC protocol for IL-36 Gamma antibody 24723-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

J Cutan Pathol

IL-36α and IL-36γ expressions in the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema: A retrospective histopathologic and immunohistochemical study.

Authors - Ozan Erdem
humanWB

Sci Immunol

Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement

Authors - Graeme P Sullivan
  • KD Validated