Product Information
27163-1-PBS targets IL-23R in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | IL-23R fusion protein Ag25939 Predict reactive species |
Full Name | interleukin 23 receptor |
Calculated Molecular Weight | 72 kDa |
Observed Molecular Weight | 65-75 kDa |
GenBank Accession Number | NM_144701 |
Gene Symbol | IL-23R |
Gene ID (NCBI) | 149233 |
RRID | AB_2880783 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Interleukin-23 receptor (IL-23R) is a type I cytokine receptor that plays a critical role in immune responses and inflammation. It forms a receptor complex with IL-12Rβ1 and is activated by the cytokine IL-23, which is primarily produced by dendritic cells and activated macrophages (PMID: 39796684). The genetic and epigenetic interactions in the IL-23R/IL-17 axis are associated with elevated expression of IL-17 and inflammatory bowel disease (IBD) pathogenesis (PMID: 21672939).