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IL-17F Monoclonal antibody, PBS Only

IL-17F Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

6H5F10

Cat no : 60245-1-PBS

Synonyms

Cytokine ML 1, IL 17F, IL17F, IL-17F, interleukin 17F, ML 1, ML1

Validation Data Gallery

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  • Western Blot (WB) analysis of human brain tissue using IL-17F Monoclonal antibody (60245-1-Ig)

    WB analysis of human brain using 60245-1-Ig (same clone as 60245-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 60245-1-Ig (IL-17F antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60245-1-PBS in a different storage buffer formulation.

Product Information

60245-1-PBS targets IL-17F in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen IL-17F fusion protein Ag16310
Full Name interleukin 17F
Calculated Molecular Weight 163 aa, 18 kDa
Observed Molecular Weight 37 kDa
GenBank Accession NumberBC070124
Gene Symbol IL-17F
Gene ID (NCBI) 112744
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17 family plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. IL-17A is a pro-inflammatory cytokine that also has the capacity to promote angiogenesis and osteoclastogenesis. IL-17F shares the highest homology with IL-17A and signals via a receptor composed by the IL-17RA and IL-17RC subunits. IL-17A and IL-17F can form IL-17A/A or IL-17F/F homodimers, IL-17A/F heterodimers are also formed. IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. IL-17F levels are elevated in sera and lesional psoriatic skin compared to non-lesional tissue. IL-17F also has been implicated in the development of neutrophilic airway inflammation.