Product Information
66145-1-PBS targets IL-16 as part of a matched antibody pair:
MP51113-1: 66145-1-PBS capture and 66145-2-PBS detection (validated in Cytometric bead array)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | IL-16 fusion protein Ag16466 Predict reactive species |
| Full Name | interleukin 16 (lymphocyte chemoattractant factor) |
| Calculated Molecular Weight | 130 aa, 15 kDa |
| Observed Molecular Weight | 37 kDa |
| GenBank Accession Number | BC040272 |
| Gene Symbol | IL-16 |
| Gene ID (NCBI) | 3603 |
| RRID | AB_2881542 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q14005 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. It is mainly produced by T lymphocytes but also by other immune cells, neuronal cells, fibroblasts and epithelial cells. The signaling process of this cytokine is mediated by CD4. IL-16 induces chemotaxis of CD4+ cells such as lymphocytes, eosinophils, and dendritic cells by ligating CD4 directly at a site distinct from other ligands. Among its multiple functions, IL-16 is a T cell chemoattractant involved in T helper cell inflammatory responses and the regulation of both T cell growth, and responsiveness to regulatory cytokines. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control.
