IL-13Ra1 Recombinant antibody, PBS Only

IL-13Ra1 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241834G10

Cat no : 84525-4-PBS

Synonyms

IL13RA1, IL 13R alpha 1, IL 13 receptor subunit alpha 1, CT19, CD213A1

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Validation Data Gallery

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  WB analysis using 84525-4-RR (same clone as 84525-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84525-4-RR (IL-13Ra1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84525-4-PBS in a different storage buffer formulation.

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Product Information

84525-4-PBS targets IL-13Ra1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: FusionProtein
• Full Name: interleukin 13 receptor, alpha 1
• Calculated Molecular Weight: 49 kDa
• Observed Molecular Weight: 70-75 kDa
• GenBank Accession Number: BC009960
• Gene Symbol: IL-13Rα1
• Gene ID (NCBI): 3597
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

IL-13 is an immunoregulatory cytokine secreted predominantly by activated T-helper 2 (Th2) cells and performs multiple functions through a complex receptor system comprised of IL-4Rα and two IL-13 binding proteins, IL-13Rα1 and IL-13Rα2 (PMID: 12704343). IL-13Rα1 is a glycosylated transmembrane protein (PMID: 10856136; 9723655). IL-13Rα1 is expressed on a wide range of cells including B cells, monocytes, macrophages, basophils, mast cells, and endothelial cells (PMID: 10856136; 31866859). IL-13 binding to the IL-4Rα/IL-13Rα1 complex leads to activation of JAK1, JAK2, and TYK2 and subsequent phosphorylation of STAT6 and STAT3 (PMID: 31866859).