IHCeasy THOC1 Ready-To-Use IHC Kit
THOC1 Ready-to-use reagent kit for IHC.
Human, Mouse, Rat
Cat no : KHC1300
HPR1, hTREX84, Nuclear matrix protein p84, P84, P84N5, THO complex 1, THO complex subunit 1, Tho1, THOC1
KHC1300 is a ready-to-use IHC kit for staining of THOC1. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.
|IHCeasy THOC1 Ready-To-Use IHC Kit
|Primary antibody type
|Secondary antibody type
|Human, Mouse, Rat
|Antigen Retrieval Buffer
|100 mL ×2
|Chromogen Component A
|Chromogen Component B
|Counter Staining Reagent
THOC1 (THO complex subunit 1), also known as Tho1, P84, HPR1 or P84N5, is a 657 amino acid nuclear matrix protein and is evolutionarily conserved from yeast to humans. THOC1 contains one death domain and is a component of the heteromultimeric THO/TREX (transcription/export) complex along with THOC2, THOC3, BAT1 and ALY. The THO/TREX complex is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. THOC1 is expressed at high levels in breast cancer cells and at relatively low levels in normal epithelia. A reduction of THOC1 in cancer cell lines results in promoted cancer cell apoptosis and reduced cell proliferation. This suggests that cancer cells are dependent on the high levels of THOC1 expression and therefore THOC1 may be a good target for cancer therapy.
|All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt.
|HPR1, hTREX84, Nuclear matrix protein p84, P84, P84N5, THO complex 1, THO complex subunit 1, Tho1, THOC1