IHCeasy SREBF1 Ready-To-Use IHC Kit
SREBF1 Ready-to-use reagent kit for IHC.
Human, Mouse, Rat
Cat no : KHC1587
bHLHd1, SREBF1, SREBP 1, SREBP 1c, SREBP1
KHC1587 is a ready-to-use IHC kit for staining of SREBF1. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.
|IHCeasy SREBF1 Ready-To-Use IHC Kit
|Primary antibody type
|Secondary antibody type
|Human, Mouse, Rat
|Antigen Retrieval Buffer
|100 mL ×2
|Chromogen Component A
|Chromogen Component B
|Counter Staining Reagent
SREBF1, also named as BHLHD1 and SREBP1, contains one basic helix-loop-helix (bHLH) domain and belongs to the SREBP family. It is a transcriptional activator required for lipid homeostasis. The SREBPs are synthesized as precursors anchored to endoplasmic reticulum (ER) membranes and complexed with SCAP. When the cellular cholesterol level is low, SREBP-SCAP complexes move to the Golgi apparatus, where SREBPs undergo a two-step proteolytic processing, leading to the release of the mature form, an N-terminal fragment, i.e, basic helix-loop-helix leucine zipper transcription factor. These factors enter the nucleus where they bind to sterol regulatory elements (SRE) in the promoter regions of a number of genes whose products mediate the synthesis of cholesterol and fatty acids.
|All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt.
|bHLHd1, SREBF1, SREBP 1, SREBP 1c, SREBP1