IHCeasy Phospho-TDP43 (Ser409/410) Ready-To-Use IHC Kit
Phospho-TDP43 (Ser409/410) Ready-to-use reagent kit for IHC.
Cat no : KHC0291
ALS10, Phospho-TDP43 (Ser409/410), TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43, tdp-43
KHC0291 is a ready-to-use IHC kit for staining of Phospho-TDP43 (Ser409/410). The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.
|IHCeasy Phospho-TDP43 (Ser409/410) Ready-To-Use IHC Kit
|Primary antibody type
|Secondary antibody type
|Antigen Retrieval Buffer
|100 mL ×2
|Chromogen Component A
|Chromogen Component B
|Counter Staining Reagent
Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). Primary antibody in this kit recognizing TDP-43 only when phosphorylated at 409/410. Immunohistochemical analyses using this primary antibody only stain the insoluble inclusions in pathologic tissues without normal diffuse nuclear staining.
|All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt.
|ALS10, Phospho-TDP43 (Ser409/410), TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43, tdp-43