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IGFBP6 Recombinant antibody, PBS Only

IGFBP6 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241724H5

Cat no : 84364-5-PBS

Synonyms

IGF-binding protein 6, IGF binding protein 6, IBP-6, IBP6, IBP 6

Validation Data Gallery

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  • Western Blot (WB) analysis of human testis tissue using IGFBP6 Recombinant antibody (84364-5-RR)

    WB analysis of human testis using 84364-5-RR (same clone as 84364-5-PBS)

    human testis tissue were subjected to SDS PAGE followed by western blot with 84364-5-RR (IGFBP6 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84364-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84364-5-RR

    Affinity and Kinetic Characterization of 84364-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84364-5-RR against Human IGFBP6 were performed. The affinity constant is 0.259 nM.

Product Information

84364-5-PBS targets IGFBP6 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein
Full Name insulin-like growth factor binding protein 6
Calculated Molecular Weight 25 kDa
Observed Molecular Weight34 kDa
GenBank Accession NumberBC011708
Gene Symbol IGFBP6
Gene ID (NCBI) 3489
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Insulin-like growth factor (IGF) binding protein (IGFBP6), a 240 amino acid protein, contains an IGFBP N-terminal domain and a thyroglobulin type-1 domain. It modulates the activity of IGF and shows independent effects of IGF, such as growth inhibition and apoptosis. It can decrease the proliferation and survival of cancer cells such as lung cancer cells and naso-pharyngeal cancer cells. IGFBP-6 is distinctive for its 50-fold higher binding affinity for IGF-II over IGF-I and this specificity makes it an attractive potential therapeutic candidate for IGF-II-dependent pediatric malignancies such as rhabdomyosarcoma (RMS). In addition, it was found that IGFBP6 can promote the migration of RMS cells in an IGF-independent manner, and MAPK pathways were involved in this process. Further study reported that IGFBP6 is one of most highly expressed proteins in varicose vein tissues and is involved in the proliferation of vascular smooth muscle cells (VSMCs), which may provide insights into the underlying pathogenesis of varicose vein.