ICAM5 Polyclonal antibody, PBS Only

• 

  WB analysis of mouse brain using 12759-1-AP (same clone as 12759-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12759-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse brain using 12759-1-AP (same clone as 12759-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12759-1-PBS in a different storage buffer formulation.

ICAM5 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 12759-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

---

Product Information

12759-1-PBS targets ICAM5 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ICAM5 fusion protein Ag3303
• Full Name: intercellular adhesion molecule 5, telencephalin
• Calculated Molecular Weight: 924 aa, 97 kDa
• Observed Molecular Weight: 140 kDa
• GenBank Accession Number: BC026338
• Gene Symbol: ICAM5
• Gene ID (NCBI): 7087
• RRID: AB_10644149
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9UMF0
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

ICAM-5, also known as telencephalin, is a type I integral membrane glycoprotein of the immunoglobulin superfamily. It is specifically expressed in the postnatal excitatory neuronal cell bodies, dendritic shafts, and dendritic filopodia of the telencephalon. ICAM-5 functions in both the immune and nervous systems. ICAM-5 strongly stimulates neurite outgrowth. It is cleaved by matrix metalloproteases upon activation of glutamate receptors or degraded through endocytosis resulting in increased spine maturation. The cleaved soluble fragment of ICAM-5 is immunosuppressive, which may be important in neuronal inflammatory diseases. (PMID: 10402269; 17682049; 25300135)