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ICAM5 Polyclonal antibody, PBS Only

ICAM5 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 12759-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse brain tissue using ICAM5 Polyclonal antibody (12759-1-AP)

    WB analysis of mouse brain using 12759-1-AP (same clone as 12759-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12759-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of mouse brain tissue using ICAM5 Polyclonal antibody (12759-1-AP)

    WB analysis of mouse brain using 12759-1-AP (same clone as 12759-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12759-1-PBS in a different storage buffer formulation.

Product Information

12759-1-PBS targets ICAM5 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ICAM5 fusion protein Ag3303
Full Name intercellular adhesion molecule 5, telencephalin
Calculated Molecular Weight 924 aa, 97 kDa
Observed Molecular Weight 140 kDa
GenBank Accession NumberBC026338
Gene Symbol ICAM5
Gene ID (NCBI) 7087
RRIDAB_10644149
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

ICAM-5, also known as telencephalin, is a type I integral membrane glycoprotein of the immunoglobulin superfamily. It is specifically expressed in the postnatal excitatory neuronal cell bodies, dendritic shafts, and dendritic filopodia of the telencephalon. ICAM-5 functions in both the immune and nervous systems. ICAM-5 strongly stimulates neurite outgrowth. It is cleaved by matrix metalloproteases upon activation of glutamate receptors or degraded through endocytosis resulting in increased spine maturation. The cleaved soluble fragment of ICAM-5 is immunosuppressive, which may be important in neuronal inflammatory diseases. (PMID: 10402269; 17682049; 25300135)