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Recombinant Human PTPRS protein (His tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His tag

Activity

not tested

Cat no : Eg0576

Validation Data Gallery

  • Purity of Recombinant Human PTPRS was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human PTPRS was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human PTPRS protein Val825-Leu1000 (Accession# Q13332-1) with a His tag at the C-terminus.
GeneID 5802
Accession Q13332-1
PredictedSize 19.8 kDa
SDS-PAGE 20-28 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Protein tyrosine phosphatase receptor type S (PTPRS, also known as R-PTP-S, PTPSIGMA, and R-PTP-sigma) is an integral membrane protein. It can promote oligomerization by binding to large heparan sulfate proteoglycan structures, and interact with NTRK1/3, PPFIA1/2/3 (PMID: 25385546; 8524829; 9624153). The non-glycosylated molecular weight of PTPRS is 214 kDa, and the extracellular domain can be cleaved near the cell membrane by an endoprotease to generate a glycated 140 kDa protein. Variations and mutations of PTPRS are associated with Alzheimer's disease and cholangiocarcinoma (PMID: 38766183; 35991009).

References:

1. Coles CH, Mitakidis N. Nat Commun. 11;5:5209(2014).
2. Pulido R, Serra-Pagès C, Tang M. Proc Natl Acad Sci USA. 5;92(25):11686-90(1995).
3. Serra-Pagès C, Medley QG. J Biol Chem. 19;273(25):15611-20(1998). 
4. Poirier A, Picard C, Labonté A. bioRxiv [Preprint]. 12:2024.05.12.593733(2024).
5. Lertpanprom M, Silsirivanit A. Front Public Health. 1;10:835914(2022).