|Positive WB detected in||mouse lung tissue, mouse small intestine tissue, rat lung tissue|
|Western Blot (WB)||WB : 1:500-1:3000|
|Sample-dependent, check data in validation data gallery|
11419-1-AP targets HOPX in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||HOPX fusion protein Ag1979|
|Full Name||HOP homeobox|
|Calculated molecular weight||73 aa, 8 kDa|
|Observed molecular weight||8-12 kDa|
|GenBank accession number||BC014225|
|Gene ID (NCBI)||84525|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
HOPX (Homeodomain-only protein) gene has various synonyms including HOD, HOP, OB1, LAGY and NECC1. The protein encoded by this gene is an unusual homeodomain protein that lacks certain conserved residues required for DNA binding. HOPX has diverse effects on cardiac growth. Manipulation of Hopx function in murine models is associated with cardiac hypertrophy, dilation and fibrosis. HOPX protein acts as an antagonist to the serum response factor (SRF), which regulates the opposing processes of cell proliferation and differentiation. Overexpression of HOPX causes cardiac hypertrophy. HOPX protein can inhibit SRF-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity.
Cell stress in cortical organoids impairs molecular subtype specification.
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.
BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Ana (Verified Customer) (11-10-2020)
We recently published with this paper: PubMed ID: 32819430 Images are within the manuscript.Protocol information: We used Citirc Acid Buffer Antigen Retrieval
Nicole (Verified Customer) (07-23-2019)
Used to mark stem cell cultures for differentiation into neural like cells