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HDAC3 Monoclonal antibody, PBS Only

HDAC3 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3E8F10

Cat no : 67151-1-PBS

Synonyms

HD3, HDAC, HDAC3, histone deacetylase 3, RPD3, RPD3 2, SMAP45

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using HDAC3 Monoclonal antibody (67151-1-Ig)

    WB analysis using 67151-1-Ig (same clone as 67151-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67151-1-Ig (HDAC3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67151-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HSC-T6 cells using HDAC3 Monoclonal antibody (67151-1-Ig)

    WB analysis of HSC-T6 using 67151-1-Ig (same clone as 67151-1-PBS)

    HSC-T6 cells were subjected to SDS PAGE followed by western blot with 67151-1-Ig (HDAC3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67151-1-PBS in a different storage buffer formulation.

Product Information

67151-1-PBS targets HDAC3 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Reactivity Human, mouse, rat
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen HDAC3 fusion protein Ag28464
Full Name histone deacetylase 3
Calculated Molecular Weight 49 kDa
Observed Molecular Weight49 kDa
GenBank Accession NumberBC000614
Gene Symbol HDAC3
Gene ID (NCBI) 8841
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the (-amino groups of lysines located near the amino termini of core histone proteins. At least 4 classes of HDAC were identified. HDAC3 is a class I HDAC. HDAC3 has histone deacetylase activity and may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. The gene encoding HDAC3 is regarded as a potential tumor suppressor gene.