HDAC11 Polyclonal antibody

HDAC11 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 12204-1-AP

Synonyms

Histone deacetylase 11, HD11, EC:3.5.1.98

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Validation Data Gallery

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  WB analysis using 12204-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 12204-1-AP (HDAC11 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse brain tissue, rat brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

12204-1-AP targets HDAC11 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: HDAC11 fusion protein Ag2848
• Full Name: histone deacetylase 11
• Calculated Molecular Weight: 347 aa, 39 kDa
• Observed Molecular Weight: 38 kDa
• GenBank Accession Number: BC009676
• Gene Symbol: HDAC11
• Gene ID (NCBI): 79885
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Histone deacetylases(HDAC) are a class of enzymes that remove the acetyl groups from the lysine residues leading to the formation of a condensed and transcriptionally silenced chromatin. At least 4 classes of HDAC were identified. HDAC11 belongs to Class IV HDACs. HDAC11 is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. This antibody is a rabbit polyclonal antibody raised against full length HDAC11 of human origin.