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GSDMC Polyclonal antibody, PBS Only

GSDMC Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 30469-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using GSDMC Polyclonal antibody (30469-1-AP)

    WB analysis using 30469-1-AP (same clone as 30469-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30469-1-AP (GSDMC antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30469-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using GSDMC Polyclonal antibody (30469-1-AP)

    WB analysis using 30469-1-AP (same clone as 30469-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30469-1-AP (GSDMC antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30469-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of Human bowens disease using GSDMC Polyclonal antibody (30469-1-AP)

    IHC staining of Human bowens disease using 30469-1-AP (same clone as 30469-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brown disease slide using 30469-1-AP (GSDMC antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30469-1-PBS in a different storage buffer formulation.

Product Information

30469-1-PBS targets GSDMC in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GSDMC fusion protein Ag33319
Full Name gasdermin C
Calculated Molecular Weight58kd
Observed Molecular Weight58 kDa
GenBank Accession NumberNM_031415
Gene Symbol GSDMC
Gene ID (NCBI) 56169
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Gasdermin (GSDM) superfamily consists of Gasdermin family genes (GSDMA, GSDMB, GSDMC and GSDMD in humans) and Gasdermin-related genes (DFNA5, DFNB59 in humans). GSDM family members were shown to be detected in the epithelium of various tissue types in a highly tissue-specific manner and suggested to have differentiation-status specific roles. Gasdermin C (GSDMC) was known as melanoma-derived leucine zipper-containing extranuclear factor (MLZE). Several studies have suggested that GSDMC may be involved in the course of tumorigenesis such as acquisition of metastatic potential in melanoma cells or promotion of cell proliferation in colorectal carcinogenesis and that GSDMC may function as an oncogene. (PMID: 29428815)