GSDMC Polyclonal antibody, PBS Only

• 

  WB analysis using 30469-1-AP (same clone as 30469-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30469-1-AP (GSDMC antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30469-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 30469-1-AP (same clone as 30469-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30469-1-AP (GSDMC antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30469-1-PBS in a different storage buffer formulation.

• 

  IHC staining of Human bowens disease using 30469-1-AP (same clone as 30469-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brown disease slide using 30469-1-AP (GSDMC antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30469-1-PBS in a different storage buffer formulation.

GSDMC Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 30469-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

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Product Information

30469-1-PBS targets GSDMC in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: GSDMC fusion protein Ag33319
• Full Name: gasdermin C
• Calculated Molecular Weight: 58kd
• Observed Molecular Weight: 58 kDa
• GenBank Accession Number: NM_031415
• Gene Symbol: GSDMC
• Gene ID (NCBI): 56169
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9BYG8
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Gasdermin (GSDM) superfamily consists of Gasdermin family genes (GSDMA, GSDMB, GSDMC and GSDMD in humans) and Gasdermin-related genes (DFNA5, DFNB59 in humans). GSDM family members were shown to be detected in the epithelium of various tissue types in a highly tissue-specific manner and suggested to have differentiation-status specific roles. Gasdermin C (GSDMC) was known as melanoma-derived leucine zipper-containing extranuclear factor (MLZE). Several studies have suggested that GSDMC may be involved in the course of tumorigenesis such as acquisition of metastatic potential in melanoma cells or promotion of cell proliferation in colorectal carcinogenesis and that GSDMC may function as an oncogene. (PMID: 29428815)