GPR17 Polyclonal antibody, PBS Only

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  IHC staining of mouse cerebellum using 13416-1-AP (same clone as 13416-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 13416-1-AP (GPR17 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13416-1-PBS in a different storage buffer formulation.

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  IF Staining of mouse cerebellum using 13416-1-AP (same clone as 13416-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using GPR17 antibody (13416-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13416-1-PBS in a different storage buffer formulation.

GPR17 Polyclonal Antibody for IHC, IF-P, Indirect ELISA

Cat No. 13416-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, IF-P, Indirect ELISA

Synonyms

UDP/CysLT receptor, R12, P2Y-like receptor, P2Y like receptor, G-protein coupled receptor 17

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Product Information

13416-1-PBS targets GPR17 in IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: GPR17 fusion protein Ag4106
• Full Name: G protein-coupled receptor 17
• Calculated Molecular Weight: 367 aa, 41 kDa
• Observed Molecular Weight: 50 kDa
• GenBank Accession Number: BC031653
• Gene Symbol: GPR17
• Gene ID (NCBI): 2840
• RRID: AB_2279341
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q13304
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

GPR17 is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, particularly in the central nervous system (CNS). GPR17 is considered a modulator of CNS myelination and is involved in reconstructing and repairing demyelinating plaques caused by ongoing inflammatory processes, such as in multiple sclerosis (MS). It is present in nerve cells and precursor oligodendrocyte cells, playing a role in the differentiation and maturation of oligodendrocytes (PMID: 32182666). GPR17 is a multifaceted GPCR with implications in immune regulation, glucose metabolism, neurodegenerative diseases, and potentially in treating anxiety disorders.