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GPR17 Polyclonal antibody, PBS Only

GPR17 Polyclonal Antibody for IF-P, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IF-P, Indirect ELISA

Conjugate

Unconjugated

Cat no : 13416-1-PBS

Synonyms

UDP/CysLT receptor, R12, P2Y-like receptor, P2Y like receptor, G-protein coupled receptor 17

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of mouse cerebellum tissue using GPR17 Polyclonal antibody (13416-1-AP)

    IF Staining of mouse cerebellum using 13416-1-AP (same clone as 13416-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using GPR17 antibody (13416-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13416-1-PBS in a different storage buffer formulation.

Product Information

13416-1-PBS targets GPR17 in IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GPR17 fusion protein Ag4106
Full Name G protein-coupled receptor 17
Calculated Molecular Weight 367 aa, 41 kDa
Observed Molecular Weight 50 kDa
GenBank Accession NumberBC031653
Gene Symbol GPR17
Gene ID (NCBI) 2840
RRIDAB_2279341
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

GPR17 is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, particularly in the central nervous system (CNS). GPR17 is considered a modulator of CNS myelination and is involved in reconstructing and repairing demyelinating plaques caused by ongoing inflammatory processes, such as in multiple sclerosis (MS). It is present in nerve cells and precursor oligodendrocyte cells, playing a role in the differentiation and maturation of oligodendrocytes (PMID: 32182666). GPR17 is a multifaceted GPCR with implications in immune regulation, glucose metabolism, neurodegenerative diseases, and potentially in treating anxiety disorders.