GPNMB Polyclonal antibody

• Featured Product
• KD/KO Validated

GPNMB Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

WB, IF, IHC, ELISA

Conjugate

Unconjugated

Publications

8

Cat no : 20338-1-AP

Synonyms

GPNMB, HGFIN, Transmembrane glycoprotein NMB

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Validation Data Gallery

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Published Applications

• KD/KO: See 1 publications below
• WB: See 3 publications below
• IHC: See 4 publications below
• IF: See 1 publications below

Product Information

The immunogen of 20338-1-AP is GPNMB Fusion Protein expressed in E. coli.

• Tested Reactivity: human, mouse
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: GPNMB fusion protein Ag14124
• Full Name: glycoprotein (transmembrane) nmb
• Calculated Molecular Weight: 64 kDa
• Observed Molecular Weight: 68 kDa
• GenBank Accession Number: BC011595
• Gene Symbol: GPNMB
• Gene ID (NCBI): 10457
• RRID: AB_10667459
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

GPNMB also known as HGFIN, osteoactivin, and DC-HIL, is a type I membrane glycoprotein involved in various biological processes, including inflammation, invasion and metastasis of malignant tumors, cell differentiation, and tissue regeneration. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB acts as an osteogenic factor that stimulates osteoblast differentiation in vivo and in vitro.

Publications

Species	Application	Title
		J Cell Physiol; Transcriptome analysis reveals GPNMB as a potential therapeutic target for gastric cancer.; Authors - Feifei Ren
human	IHC	BMC Med Genomics; Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization.; Authors - Shi Zhi-Zhou ZZ
mouse	WB	Int J Mol Sci; Ocular Albinism Type 1 Regulates Melanogenesis in Mouse Melanocytes.; Authors - Tianzhi Chen
human	WB,IHC	Inflammation; Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease.; Authors - Rong Song
human	IHC	Pathol Oncol Res; GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma-Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis; Authors - Yohei Kawasaki
mouse	WB	J Biomater Appl; The anti-inflammatory and osteogenic activity of chitosan/polyvinyl alcohol/graphene oxide/astaxanthin nanofibers membranes in vitro study.; Authors - Xuan Dang