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GNRHR Recombinant antibody, PBS Only

GNRHR Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

7E11

Cat no : 82847-1-PBS

Synonyms

GnRH R, GnRH receptor, GNRHR, GNRHR1, GRHR, LHRHR, LRHR

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using GNRHR Recombinant antibody (82847-1-RR)

    WB analysis using 82847-1-RR (same clone as 82847-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 82847-1-RR (GNRHR antibody) at dilution of 1:5100 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82847-1-PBS in a different storage buffer formulation.

Product Information

82847-1-PBS targets GNRHR in WB, Indirect ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide
Full Name GnRH receptor
Calculated Molecular Weight 38 kDa
Observed Molecular Weight~38 kDa
GenBank Accession NumberNM_000406
Gene Symbol GNRHR
Gene ID (NCBI) 2798
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

GNRHR, also named GRHR, belongs to the G-protein coupled receptor 1 family. GNRHR is a receptor for GnRH that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform2 of GNRHR may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Defects in GNRHR are a cause of fertile eunuch syndrome. The predicted unmodified molecular weight of the human GNRHR is ~38 kDa, the larger band (50-65 kDa) is likely to represent a glycosylated form of GNRHR.