GEFT Polyclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

GEFT Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 51004-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis using 51004-1-AP (same clone as 51004-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 51004-1-AP (GEFT antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51004-1-PBS in a different storage buffer formulation.

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Product Information

51004-1-PBS targets GEFT in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: RhoA/RAC/CDC42 exchange factor
• Calculated Molecular Weight: 64 kDa
• Observed Molecular Weight: 70 kDa
• GenBank Accession Number: BC047559
• Gene Symbol: GEFT
• Gene ID (NCBI): 115557
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

GEFT, also named as p63RhoGEF, may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. GETF links specifically G alpha q/11-coupled receptors to RHOA activation. GEFT may be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. It is involved in skeletal myogenesis. GEFT is expressed as three isoforms (64, 53 and 68kDa).