GDAP1L1 Monoclonal antibody

GDAP1L1 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, mouse, rat, pig, rabbit

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1C7A3

Cat no : 68340-1-Ig

Synonyms

dJ881L22.1, dJ995J12.1.1, DKFZp761K228, GDAP1 L1, GDAP1L1

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Validation Data Gallery

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  WB analysis using 68340-1-Ig

  Various lysates were subjected to SDS PAGE followed by western blot with 68340-1-Ig (GDAP1L1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: fetal human brain tissue, pig brain tissue, rabbit brain tissue, rat brain tissue, mouse brain tissue, pig cerebellum tissue, rabbit cerebellum tissue, rat cerebellum tissue, mouse cerebellum tissue

Recommended dilution

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

68340-1-Ig targets GDAP1L1 in WB, ELISA applications and shows reactivity with Human, mouse, rat, pig, rabbit samples.

• Tested Reactivity: Human, mouse, rat, pig, rabbit
• Host / Isotype: Mouse / IgG2b
• Class: Monoclonal
• Type: Antibody
• Immunogen: GDAP1L1 fusion protein Ag27717
• Full Name: ganglioside-induced differentiation-associated protein 1-like 1
• Calculated Molecular Weight: 367 aa, 42 kDa
• Observed Molecular Weight: 38-40 kDa
• GenBank Accession Number: BC009014
• Gene Symbol: GDAP1L1
• Gene ID (NCBI): 78997
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1L1) belongs to GST superfamily. Owing to its central role in mitochondrial fission, GDAP1L1 is a homologue of GDAP1 implicated in cellular processes, such as cell death, autophagy, aging, and immune response regulation (PMID:32230997). GDAP1L1, a fission factor controlling mitochondrial fission, induces fission upon translocation from the cytosol to mitochondria in response to stress condition (PMID:34638757). Furthermore, the activity of GDAP1L1 is dependent on Drp1. GDAP1, a paralog of GDAP1L1, evokes mitochondrial fragmentation only in the presence of Drp1 in HeLa cells (PMID:19782751).