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GBP2 Monoclonal antibody, PBS Only

GBP2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2D7G4

Cat no : 68559-1-PBS

Synonyms

GBP 2, GBP2, GTP binding protein 2, HuGBP 2

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using GBP2 Monoclonal antibody (68559-1-Ig)

    WB analysis using 68559-1-Ig (same clone as 68559-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68559-1-Ig (GBP2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68559-1-PBS in a different storage buffer formulation.

Product Information

68559-1-PBS targets GBP2 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen GBP2 fusion protein Ag24108
Full Name guanylate binding protein 2, interferon-inducible
Calculated Molecular Weight 591 aa, 67 kDa
Observed Molecular Weight 67 kDa
GenBank Accession NumberBC022272
Gene Symbol GBP2
Gene ID (NCBI) 2634
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

GBP2 is a member of the GTPase family and is crucial to host immunity against pathogens. GBP2 is also used as a marker of interferon (IFN) responsiveness, because it is one of the most highly expressed genes after IFN-γ stimulation. Increased GBP2 expression is also associated with a better prognosis in breast cancer and may have a role in T-cell defense against breast cancer. Interestingly, GBP2 expression in NIH/3T3 fibroblasts inhibited Rac activation and matrix metalloproteinase-9 expression, suggesting a possible role for GBP2 in regulating cancer metastasis. The molecular weight of GBP2 is 67 kDa. (PMID: 29072687, 35383115)