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GABRA6 Polyclonal antibody, PBS Only

GABRA6 Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 21766-1-PBS

Synonyms

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of mouse cerebellum tissue using GABRA6 Polyclonal antibody (21766-1-AP)

    IHC staining of mouse cerebellum using 21766-1-AP (same clone as 21766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21766-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse cerebellum tissue using GABRA6 Polyclonal antibody (21766-1-AP)

    IHC staining of mouse cerebellum using 21766-1-AP (same clone as 21766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21766-1-PBS in a different storage buffer formulation.

Product Information

21766-1-PBS targets GABRA6 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GABRA6 fusion protein Ag16375
Full Name gamma-aminobutyric acid (GABA) A receptor, alpha 6
Calculated Molecular Weight 453 aa, 51 kDa
GenBank Accession NumberBC096241
Gene Symbol GABRA6
Gene ID (NCBI) 2559
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. GABAA receptors are formed by pentameric assembly of 19 different subunit subtypes (α1-α6, β1-β3, γ1-γ3, δ, ɛ, π, θ and ρ1-ρ3) (PMID: 21930603). The mutation R46W of GABRA6 is associated with the pathogenesis of childhood absence epilepsy (CAE) (PMID: 21930603).