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GABPA Monoclonal antibody, PBS Only

GABPA Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Mouse, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2A7E3

Cat no : 68645-1-PBS

Synonyms

E4TF1 60, E4TF1A, GA binding protein alpha chain, GABP subunit alpha, GABPA, NFT2, Transcription factor E4TF1 60

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using GABPA Monoclonal antibody (68645-1-Ig)

    WB analysis using 68645-1-Ig (same clone as 68645-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68645-1-Ig (GABPA antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68645-1-PBS in a different storage buffer formulation.

Product Information

68645-1-PBS targets GABPA in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Reactivity Human, Mouse, Rat
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen GABPA fusion protein Ag33705
Full Name GA binding protein transcription factor, alpha subunit 60kDa
Calculated Molecular Weight 454 aa, 51 kDa
Observed Molecular Weight 56-60 kDa
GenBank Accession NumberBC035031
Gene Symbol GABPA
Gene ID (NCBI) 2551
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

GA-binding protein alpha chain (GABP alpha subunit, GABPA, nuclear respiratory factor 2 subunit alpha, transcription factor E4TF1-60) is one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit.GABPA is a member of Ets family, binds to the Yap promoter and activates YAP transcription(23684612). Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.