Product Information
82080-4-PBS targets G3BP2 as part of a matched antibody pair:
MP00090-1: 82080-4-PBS capture and 82080-3-PBS detection (validated in Cytometric bead array)
MP00090-2: 82080-4-PBS capture and 82080-5-PBS detection (validated in Cytometric bead array)
MP00090-3: 82080-4-PBS capture and 82080-2-PBS detection (validated in Cytometric bead array, Sandwich ELISA)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | G3BP2 fusion protein Ag9355 Predict reactive species |
Full Name | GTPase activating protein (SH3 domain) binding protein 2 |
Calculated Molecular Weight | 482aa,54 kDa; 449aa,51 kDa |
Observed Molecular Weight | 65-70 kDa |
GenBank Accession Number | BC011731 |
Gene Symbol | G3BP2 |
Gene ID (NCBI) | 9908 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q9UN86 |
Storage Buffer | 100% PBS pH 7.3 |
Storage Conditions | Store at -80°C. |
Background Information
Stress granules (SGs) are cytoplasmic mRNA-protein condensates formed in response to cellular stressors, such as oxidative stress, ultraviolet radiation, and viral infection (1). The Ras-GTPase-activating protein-binding proteins (G3BPs), consisting of G3BP1 and G3BP2, are key nucleating factors essential for SG formation. They function to protect RNAs from harmful conditions. G3BP2 is mainly distributed in the cytoplasm and participates in the formation of stress granules, cell differentiation, proliferation, and signal transduction. Accumulating evidence has demonstrated that aberrant expression of G3BP2 contributes to cancer initiation and progression, such as high expression of G3BP2 increasing cell stemness, metastasis and chemoresistance in breast cancer.