FcRn Monoclonal antibody, PBS Only

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  WB analysis using 67944-1-Ig (same clone as 67944-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67944-1-Ig (FcRn antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 67944-1-Ig (FcRn antibody) at dilution of 1:10000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 67944-1-Ig (FcRn antibody) at dilution of 1:10000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

FcRn Monoclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 67944-1-PBS

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, IHC, Indirect ELISA

Synonyms

alpha chain, FCGRT, FCRN, Neonatal Fc receptor

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Product Information

67944-1-PBS targets FcRn in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: FcRn fusion protein Ag31173
• Full Name: Fc fragment of IgG, receptor, transporter, alpha
• Calculated Molecular Weight: 40 kDa
• Observed Molecular Weight: 35-40 kDa
• GenBank Accession Number: BC008734
• Gene Symbol: FcRn
• Gene ID (NCBI): 2217
• RRID: AB_2918696
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• UNIPROT ID: P55899
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).