Follistatin Polyclonal antibody
Follistatin Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (2)
Applications
WB, IHC, ELISA
Conjugate
Unconjugated
Cat no : 10474-1-AP
Synonyms
Validation Data Gallery
Published Applications
| WB | See 1 publications below |
| IHC | See 4 publications below |
Product Information
10474-1-AP targets Follistatin in WB, IHC, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Follistatin fusion protein Ag0775 |
| Full Name | follistatin |
| Calculated Molecular Weight | 33 aa, 7 kDa |
| GenBank Accession Number | BC004107 |
| Gene Symbol | Follistatin |
| Gene ID (NCBI) | 10468 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor11 , and myostatin. It binds activin A with high affinity and whose expression can be induced by activin A and several other pro-inflammatory cytokines. Activin A-follistatin complexes are biologically inactive and bind to cell surface heparan sulphate-containing proteoglycans for internalisation and degradation. It has also been found to play a significant role in the management of skeletal muscle size and mass. It also has important roles in early embryonic development, differentiation of ovarian granulosa cells, liver fibrosis and polycystic ovarian syndrome.
Publications
| Species | Application | Title |
|---|---|---|
Am J Pathol Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia. | ||
Mol Pharm Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis. | ||
Cell Commun Signal Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells. | ||
J Int Med Res Expression of activin A and follistatin in glioblastoma and their effects on U87 in vitro. |
