- Featured Product
- KD/KO Validated
FOLR1 Polyclonal antibody, PBS Only
FOLR1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IHC, IF/ICC, Indirect ELISA
Conjugate
Unconjugated
Cat no : 23355-1-PBS
Synonyms
Validation Data Gallery
Product Information
23355-1-PBS targets FOLR1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | FOLR1 fusion protein Ag19959 |
Full Name | folate receptor 1 (adult) |
Calculated Molecular Weight | 257 aa, 30 kDa |
Observed Molecular Weight | 38 kDa |
GenBank Accession Number | BC002947 |
Gene Symbol | FOLR1 |
Gene ID (NCBI) | 2348 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Folate receptor 1 (FOLR1), also known as folate receptor alpha or adult folate-binding protein (FBP), is a 38-kDa glycoprotein belonging to the folate receptor family (PMID:15094207; 23528302). The receptor binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. FOLR1 expression is often limited to the apical surfaces of epithelium in the lung, kidney and choroid plexus but is differentially overexpressed in a variety of solid tumors such as ovarian cancer, non-small cell lung cancer, breast cancer, kidney cancer and high-grade osteosarcoma (PMID: 23528302; 23357463).