Product Information
98106-1-PBS targets FLT3/CD135 in FC applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Recombinant Protein Predict reactive species |
Full Name | fms-related tyrosine kinase 3 |
Calculated Molecular Weight | 993 aa, 113 kDa |
GenBank Accession Number | BC036028 |
Gene Symbol | FLT3 |
Gene ID (NCBI) | 2322 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | P36888 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
FLT3 (also known as CD135 or FLK2) is a tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. FLT3 was originally identified by its expression in hematopoietic stem/progenitor cells (PMID: 7507245). It is important for the normal development of hematopoietic stem/progenitor cells. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.