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Anti-Human FLT3/CD135 Rabbit Recombinant Antibody, PBS Only

FLT3/CD135 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241414F8

Cat no : 98106-1-PBS

Synonyms

FLT3, FLK2, FL cytokine receptor, Fetal liver kinase-2, EC:2.7.10.1

Validation Data Gallery

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  • Flow cytometry (FC) experiment of Reh cells using Anti-Human FLT3/CD135 Rabbit Recombinant Antibody (98106-1-RR)

    FC experiment of Reh using 98106-1-RR (same clone as 98106-1-PBS)

    1x10^6 Reh cells (left) or U-937 cells (right) were surface stained with 0.25 ug Anti-Human FLT3 Rabbit Recombinant Antibody (98106-1-RR, Clone:241414F8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98106-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98106-1-RR

    Affinity and Kinetic Characterization of 98106-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98106-1-RR against Human FLT3/CD135 were performed. The affinity constant is 1.25 nM.

Product Information

98106-1-PBS targets FLT3/CD135 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant Protein
Full Name fms-related tyrosine kinase 3
Calculated Molecular Weight 993 aa, 113 kDa
GenBank Accession NumberBC036028
Gene Symbol FLT3
Gene ID (NCBI) 2322
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

FLT3 (also known as CD135 or FLK2) is a tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. FLT3 was originally identified by its expression in hematopoietic stem/progenitor cells (PMID: 7507245). It is important for the normal development of hematopoietic stem/progenitor cells. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.