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FKBP52 Polyclonal antibody
FKBP52 Polyclonal Antibody for FC, IF, IHC, IP, WB, ELISA
Cat no : 10655-1-AP
Validation Data Gallery
|Positive WB detected in||HeLa cells, PC-3 cells, Jurkat cells, NIH/3T3 cells, MCF-7 cells|
|Positive IP detected in||HeLa cells|
|Positive IHC detected in||human prostate cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||MCF-7 cells|
|Positive FC detected in||MCF-7 cells|
|Western Blot (WB)||WB : 1:1000-1:8000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:5000-1:50000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10655-1-AP targets FKBP52 in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse, chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||FKBP52 fusion protein Ag1019|
|Full Name||FK506 binding protein 4, 59kDa|
|Calculated molecular weight||52 kDa|
|Observed molecular weight||52 kDa|
|GenBank accession number||BC007924|
|Gene ID (NCBI)||2288|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
FKBP52 (FK506 binding protein 4) is a member of the immunophilin protein family that comprises intracellular protein effectors of immunosuppressive drugs, and it is known as a steroid receptor-associated protein. As a novel regulator of microtubule dynamics, FKBP52 is associated with the motor protein dynein and with the cytoskeleton during mitosis. FKBP52 is highly expressed in CNS regions susceptible to Alzheimer's, and plays a role in modulating toxicity of Abeta peptides. The protein can associate with the Tau function, and may help to decipher and modulate the events involved in Tau-induced neurodegeneration. In addition, FKBP52 is likely to play a role in growth and development of the male genitalia.
|Product Specific Protocols|
|WB protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|IHC protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|IF protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|IP protocol for FKBP52 antibody 10655-1-AP||Download protocol|
|Click here to view our Standard Protocols|
FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer.
Clin Cancer Res
Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women.
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
J Cell Physiol
Multiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia.
The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.
Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell.