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FGFR4 Monoclonal antibody, PBS Only

FGFR4 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1A2B5

Cat no : 67800-1-PBS

Synonyms

CD334, FGFR 4, FGFR4, JTK2, TKF

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using FGFR4 Monoclonal antibody (67800-1-Ig)

    WB analysis using 67800-1-Ig (same clone as 67800-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67800-1-Ig (FGFR4 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67800-1-PBS in a different storage buffer formulation.

Product Information

67800-1-PBS targets FGFR4 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen FGFR4 fusion protein Ag17041
Full Name fibroblast growth factor receptor 4
Calculated Molecular Weight 88 kDa
Observed Molecular Weight100-110 kDa
GenBank Accession NumberBC011847
Gene Symbol FGFR4
Gene ID (NCBI) 2264
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID:10336501).