- Featured Product
- KD/KO Validated
FGFR3 Monoclonal antibody, PBS Only
FGFR3 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human
Applications
WB, IF/ICC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1F3G1
Cat no : 66954-1-PBS
Synonyms
Validation Data Gallery
Product Information
66954-1-PBS targets FGFR3 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | FGFR3 fusion protein Ag26290 |
Full Name | fibroblast growth factor receptor 3 |
Calculated Molecular Weight | 87 kDa |
Observed Molecular Weight | 125-135 kDa |
GenBank Accession Number | NM_000142 |
Gene Symbol | FGFR3 |
Gene ID (NCBI) | 2261 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Fibroblast growth factors (FGFs) are polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing (PMID: 1847508). The human FGF receptor family, a subfamily of receptor tyrosine kinases (RTKs), comprises of four family members-FGFR1, FGFR2, FGFR3, and FGFR4 (PMID: 23900974). Each receptor contains an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. FGFR3 binds acidic and basic fibroblast GH and plays a role in bone development and maintenance. Mutations in the FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Due to frequent mutations in certain cancers, the FGFR3 gene has also been associated with tumor progression.