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  • Featured Product
  • KD/KO Validated

FANCD2 Polyclonal antibody, PBS Only

FANCD2 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28619-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using FANCD2 Polyclonal antibody (28619-1-AP)

    WB analysis using 28619-1-AP (same clone as 28619-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28619-1-AP (FANCD2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28619-1-PBS in a different storage buffer formulation.

Product Information

28619-1-PBS targets FANCD2 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FANCD2 fusion protein Ag29460
Full Name Fanconi anemia, complementation group D2
Calculated Molecular Weight 164 kDa
Observed Molecular Weight 150 kDa
GenBank Accession NumberNM_001018115
Gene Symbol FANCD2
Gene ID (NCBI) 2177
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

FANCD2, also named as FACD and FACD2, is required for maintenance of chromosomal stability. FANCD2 promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. It may participate in S phase and G2 phase checkpoint activation upon DNA damage. It promotes BRCA2/FANCD1 loading onto damaged chromatin. FANCD2 may also be involved in B-cell immunoglobulin isotype switching. Defects in FANCD2 are a cause of Fanconi anemia (FA) which is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies.