FAAP100 Polyclonal antibody

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  WB analysis using 31841-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 31841-1-AP (FAAP100 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

FAAP100 Polyclonal Antibody for WB, ELISA

Cat No. 31841-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

FLJ22175, Fanconi anemia-associated protein of 100 kDa, Fanconi anemia core complex-associated protein 100, C17orf70

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Tested Applications

• Positive WB detected in: A431 cells, HL-60 cells, Jurkat cells, SH-SY5Y cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

31841-1-AP targets FAAP100 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: FAAP100 fusion protein Ag36385
• Full Name: chromosome 17 open reading frame 70
• Calculated Molecular Weight: 93 kDa
• Observed Molecular Weight: 100 kDa
• GenBank Accession Number: BC117139
• Gene Symbol: C17orf70
• Gene ID (NCBI): 80233
• RRID: AB_3670125
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q0VG06
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

FA core complex associated protein 100 (FAAP100, also known as C17orf70) is a component of the Fanconi anemia (FA), which plays a role in the FA-associated DNA damage response network as well as regulates Fanconi anemia group D2 protein (FANCD2) monoubiquitination and the stability of the FA core complex (PMID: 17396147). FAAP100 deletion leads to FA pathway inactivation, increases TRCs and cotranscriptional R-loops, and contributes to the collapse of replication forks and the generation of DNA damage (PMID: 37580696).