Endoglin/CD105 Recombinant antibody, PBS Only
Endoglin/CD105 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
241196G9
Cat no : 82993-6-PBS
Synonyms
Validation Data Gallery
Product Information
The immunogen of 82993-6-PBS is Endoglin/CD105 Fusion Protein expressed in E. coli.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Fusion Protein |
Full Name | endoglin |
Calculated Molecular Weight | 71 kDa |
Observed Molecular Weight | 75-90 kDa |
GenBank Accession Number | BC014271 |
Gene Symbol | CD105 |
Gene ID (NCBI) | 2022 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)