Endoglin/CD105 Monoclonal antibody, PBS Only
Endoglin/CD105 Monoclonal Antibody for WB, IHC, IF-P, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
human
Applications
WB, IHC, IF-P, ELISA
Conjugate
Unconjugated
CloneNo.
2D5E8
Cat no : 67075-1-PBS
Synonyms
Validation Data Gallery
Product Information
67075-1-PBS targets Endoglin/CD105 in WB, IHC, IF-P, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | Endoglin/CD105 fusion protein Ag27837 |
Full Name | endoglin |
Calculated Molecular Weight | 71 kDa |
Observed Molecular Weight | 95-100 kDa |
GenBank Accession Number | BC014271 |
Gene Symbol | CD105 |
Gene ID (NCBI) | 2022 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)