ESRP2 Polyclonal antibody, PBS Only

ESRP2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 23117-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis using 23117-1-AP (same clone as 23117-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23117-1-AP (ESRP2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23117-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 23117-1-AP (same clone as 23117-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23117-1-AP (ESRP2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23117-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 23117-1-AP (same clone as 23117-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 23117-1-AP (ESRP2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 23117-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 23117-1-AP (same clone as 23117-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 23117-1-AP (ESRP2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 23117-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 23117-1-AP (same clone as 23117-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 23117-1-AP (ESRP2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 23117-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 23117-1-AP (same clone as 23117-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 23117-1-AP (ESRP2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 23117-1-PBS in a different storage buffer formulation.

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Product Information

23117-1-PBS targets ESRP2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ESRP2 fusion protein Ag19436
• Full Name: epithelial splicing regulatory protein 2
• Calculated Molecular Weight: 727 aa, 78 kDa
• Observed Molecular Weight: 78 kDa
• GenBank Accession Number: BC030146
• Gene Symbol: ESRP2
• Gene ID (NCBI): 80004
• RRID: AB_2879213
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

ESRP2 (Epithelial Splicing Regulatory Protein 2), also known as RBM35B(RNA binding motif protein 35B), is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of RNA binding proteins. ESRP2 plays a role in the regulation of alternative splicing events of pre-mRNAs(PMID: 27401076). Overexpression of ESRP2 has been described in various malignant tumors, such as pancreatic ductal adenocarcinoma, oral squamous carcinoma, ovarian cancer, and luminal-type breast cancer(PMID: 33339518).