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EPOR Polyclonal antibody, PBS Only

EPOR Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 30766-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using EPOR Polyclonal antibody (30766-1-AP)

    WB analysis using 30766-1-AP (same clone as 30766-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30766-1-AP (EPOR antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30766-1-PBS in a different storage buffer formulation.

Product Information

30766-1-PBS targets EPOR in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen EPOR fusion protein Ag33956
Full Name erythropoietin receptor
Calculated Molecular Weight55 kDa
Observed Molecular Weight70 kDa
GenBank Accession NumberNM_000121.4
Gene Symbol EPOR
Gene ID (NCBI) 2057
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Erythropoietin (EPO) receptor (EPOR) is a glycoprotein that belongs to the type I superfamily of single-transmembrane cytokine receptors. It consists of an extracellular domain that binds to the EPO ligand, a transmembrane domain and an intracellular domain. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK (PMID: 34281163). EPOR is present on erythroid progenitor cells and has also been detected on a wide variety of non-hematopoietic cells (PMID: 36233351). The calculated molecular weight of EPOR is 55 kDa. EPOR undergoes posttranslational modification and the apparent molecular weight of 66-78 kDa has been reported (PMID: 8943308; 12088257).