ELA2 Polyclonal antibody

ELA2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

IF, ELISA

Conjugate

Unconjugated

Publications

2

Cat no : 17943-1-AP

Synonyms

Bone marrow serine protease, ELA2, ELANE, Elastase 2, elastase 2, neutrophil, GE, HLE, HNE, Human leukocyte elastase, Medullasin, NE, Neutrophil elastase, PMN E, PMN elastase

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Validation Data Gallery

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Published Applications

• IF: See 1 publications below

Product Information

The immunogen of 17943-1-AP is ELA2 Fusion Protein expressed in E. coli.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: bovine
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ELA2 fusion protein Ag12372
• Full Name: elastase 2, neutrophil
• Calculated Molecular Weight: 267 aa, 29 kDa
• GenBank Accession Number: BC074816
• Gene Symbol: ELA2
• Gene ID (NCBI): 1991
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ELA2(Neutrophil elastase) is also named as ELAL, NE, HLE, HNE, PMN-E, SERP1, GE, ELANE and belongs to the peptidase S1 family. It is a 33-kDa enzyme with several isoforms that differ in their extent of glycosylation(PMID:12223222). Human neutrophil elastase (HNE) is a serine protease with potent proteolytic activity (3), which is reported to cause mucin secretion (degranulation)(PMID:12169572). It may contribute to the directed migration of leukocytes into flamed postcapillary venules in addition to contributing to the process of tissue emigration(PMID:9683424). The full length protein has a signal peptide,propeptide and three glycosylation sites.

Publications

Species	Application	Title
bovine	IF	Biol Trace Elem Res; Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps.; Authors - Xiechen Zhou
		Cell Death Discov; Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.; Authors - Nan Wang