EIF2S2 Monoclonal antibody, PBS Only

EIF2S2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H8E1

Cat no : 68463-1-PBS

Synonyms

DKFZp686L18198, eIF 2 beta, EIF2, EIF2B, EIF2beta, EIF2S2



Product Information

68463-1-PBS targets EIF2S2 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Reactivity Human, mouse, rat
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen EIF2S2 fusion protein Ag18349
Full Name eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Calculated Molecular Weight 38 kDa
Observed Molecular Weight50 kDa
GenBank Accession NumberBC000461
Gene Symbol EIF2S2
Gene ID (NCBI) 8894
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Eukaryotic translation initiation factor 2 (eIF2) is composed of three subunits, eIF2 alpha, eIF2 beta (EIF2S2), and eIF2 gamma, which are present in equal molar amounts. eIF2 beta plays a central role in the maintenance of what is generally considered a rate-limiting step in mRNA translation. In the early steps of protein synthesis, eIF2 beta binds GTP and Met-tRNA and transfers Met-tRNA to the 40S ribosomal subunit. At the end of the initiation process, GTP bound to eIF2 beta is hydrolyzed to GDP and the eIF2/GDP complex is released from the ribosome. The exchange of GDP bound to eIF2 beta for GTP is a prerequisite to binding Met-tRNA and is mediated by eIF2 beta, which recycles the eIF2 complex for another round of initiation.