EGFL7 Polyclonal antibody

• Featured Product
• KD/KO Validated

EGFL7 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, rat and More (1)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Publications

12

Cat no : 19291-1-AP

Synonyms

Multiple EGF-like domains protein 7, MEGF7, Epidermal growth factor-like protein 7, EGF-like protein 7, EGF like protein 7

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Validation Data Gallery

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  WB analysis using 19291-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 19291-1-AP (EGFL7 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: rat eye tissue

Recommended dilution

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 2 publications below
• WB: See 11 publications below
• IHC: See 4 publications below
• IF: See 1 publications below

Product Information

19291-1-AP targets EGFL7 in WB, IHC, IF, ELISA applications and shows reactivity with human, rat samples.

• Tested Reactivity: human, rat
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: EGFL7 fusion protein Ag6559
• Full Name: EGF-like-domain, multiple 7
• Calculated Molecular Weight: 273 aa, 30 kDa
• Observed Molecular Weight: 30 kDa
• GenBank Accession Number: BC012377
• Gene Symbol: EGFL7
• Gene ID (NCBI): 51162
• RRID: AB_10643993
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Epidermal growth factor-like domain-containing protein 7 (EGFL7), also known as vascular endothelial statin, is an endothelial cell-derived secreted factor that regulates vascular tube formation. This protein may be involved in the growth and proliferation of tumor cells. Recent studies have reported elevated expression of EGFL7 in several tumors and cancer cell lines, including kidney tumors, malignant gliomas, hepatocellular carcinomas, and colon cancers.

Publications

Species	Application	Title
human	WB	Blood Adv; The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models.; Authors - Yousef Salama ; KD Validated
human	WB	Mol Ther Nucleic Acids; Role of ANKHD1/LINC00346/ZNF655 Feedback Loop in Regulating the Glioma Angiogenesis via Staufen1-Mediated mRNA Decay.; Authors - Chunqing Yang
human	WB,IHC,IF	Front Oncol; Novel Expression of EGFL7 in Osteosarcoma and Sensitivity to Cisplatin.; Authors - Qing Liu
mouse,rat	WB	Sci China Life Sci; Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas.; Authors - Qian Liu
human	WB	Hum Gene Ther; Attenuation of EGFL7 expression inhibits growth hormone-producing pituitary adenomas growth and invasion.; Authors - Qian Liu
human	WB,IHC	Tumour Biol; EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway.; Authors - Jianpeng Wang