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DcR1/TNFRSF10C Polyclonal antibody, PBS Only

DcR1/TNFRSF10C Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 24622-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of human peripheral blood leukocyte using DcR1/TNFRSF10C Polyclonal antibody (24622-1-AP)

    WB analysis of human peripheral blood leukocyte using 24622-1-AP (same clone as 24622-1-PBS)

    human peripheral blood leukocytes were subjected to SDS PAGE followed by western blot with 24622-1-AP (DcR1/TNFRSF10C antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24622-1-PBS in a different storage buffer formulation.

Product Information

24622-1-PBS targets DcR1/TNFRSF10C in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DcR1/TNFRSF10C fusion protein Ag18399
Full Name tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Calculated Molecular Weight 259 aa, 27 kDa
Observed Molecular Weight60 kDa
GenBank Accession NumberBC125041
Gene Symbol DcR1
Gene ID (NCBI) 8794
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Decoy receptor 1 (DcR1), also known as TNFRSF10C, CD263, TRAIL-R3, or TRID, is a member of the TNF-receptor superfamily. DcR1 is a receptor for the cytotoxic ligand TRAIL. In contrast to DR4/TRAIL-R1 and DR5/TRAIL-R2, DcR1 is a glycosylphosphatidylinositol (GPI)-linked membrane molecule that lacks a cytoplasmic region, including the death domain (PMID: 9314565; 9242611). DcR1 is not capable of inducing apoptosis and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis (PMID: 9242610). The apparent molecular weight of DcR1 is larger than the calculated molecular weight of 27 kDa, suggesting the presence of extensive post-translational modifications and/or unusual structural motifs (PMID: 9373179).