DUSP6 Polyclonal antibody

DUSP6 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Publications

5

Cat no : 10433-1-AP

Synonyms

dual specificity phosphatase 6, DUSP6, MAP kinase phosphatase 3, MKP 3, MKP3, PYST1

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Validation Data Gallery

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Published Applications

• WB: See 4 publications below
• IHC: See 1 publications below

Product Information

10433-1-AP targets DUSP6 in WB, IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: DUSP6 fusion protein Ag0705
• Full Name: dual specificity phosphatase 6
• Calculated Molecular Weight: 42 kDa
• GenBank Accession Number: BC003562
• Gene Symbol: DUSP6
• Gene ID (NCBI): 1848
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).

Publications

Species	Application	Title
human	WB	Br J Pharmacol; L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia.; Authors - Yi-Ping Leng
mouse	WB	Ren Fail; LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis; Authors - Taoxia Wang
mouse	WB	Mol Cell Biochem; PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.; Authors - Jeong Hyo-Soon HS
human	IHC	Chin Med J (Engl); Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma.; Authors - Bo Yang
rat	WB	Biochim Biophys Acta; VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.; Authors - Kang Tae-Hong TH